IGKV1D-37

Across TCGA pan-cancer cohorts, IGKV1D-37 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated IGKV1D-37 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-37 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-37 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KIRC are the cancer types where IGKV1D-37 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.433	0.283	<.001	144	view →
SKCM	OS	Tertile	All	0.483	0.304	.001	78	view →
KIRC	DFS	Tertile	All	0.268	0.666	<.001	42	view →
KIRP	DFS	Tertile	III,IV	0.365	0.730	.009	39	view →
MESO	OS	Tertile	All	0.793	0.206	.019	36	view →
GBM	OS	Tertile	All	0.028	0.420	<.001	36	view →
READ	DFS	Tertile	All	0.929	0.493	.024	30	view →
STAD	DFS	Median	IV	0.670	0.173	.007	12	view →
UVM	OS	Tertile	All	0.315	0.711	.049	9	view →
PCPG	DFS	Tertile	All	0.088	0.846	.017	9	view →
THCA	OS	Tertile	IV	0.813	1.000	.039	9	view →
ESCA	DFS	Tertile	II,III,IV	0.585	0.435	.039	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

IGKV1D-37–HNSC (DFS)

Open the HNSC breakdown →