IGKV1D-35

Across TCGA pan-cancer cohorts, IGKV1D-35 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGKV1D-35 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1D-35 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV1D-35 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

HNSC, OV, and BRCA are the cancer types where IGKV1D-35 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.487	0.302	<.001	144	view →
OV	OS	Tertile	IV	0.179	0.769	.002	36	view →
BRCA	DFS	Quartile	III,IV	0.911	0.752	.002	36	view →
KICH	DFS	Tertile	All	0.121	0.867	.023	24	view →
LUAD	DFS	Quartile	All	0.809	0.638	.007	24	view →
PAAD	OS	Tertile	II,III,IV	0.690	0.515	.009	21	view →
STAD	OS	Quartile	All	0.304	0.486	.010	19	view →
READ	DFS	Tertile	IV	1.000	0.423	.005	18	view →
THCA	OS	Tertile	IV	0.466	0.871	.011	15	view →
COAD	DFS	Median	All	0.783	0.638	.026	7	view →
SKCM	OS	Median	IV	0.621	0.140	.044	3	view →
LGG	DFS	Tertile	All	0.426	0.828	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGKV1D-35–HNSC (DFS)

Open the HNSC breakdown →