Across TCGA patient cohorts, IGKV1D-27 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,926 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IGKV1D-27-associated GO terms across cancer lineages are Complement activation, Regulation of B cell proliferation, and B cell receptor signaling pathway. Each is linked with IGKV1D-27 in more than 26 cancer types. Because this analysis shows association rather than direction, both IGKV1D-27-to-partner and partner-to-IGKV1D-27 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-27→partner) and Y-score (partner→IGKV1D-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	Complement activation →	+0.144	+1.319	<.001	<.001	3	27
ESCA	Regulation of B cell proliferation →	+0.061	+1.126	<.001	<.001	3	27
STAD	B cell receptor signaling pathway →	+0.082	+1.301	<.001	<.001	3	27
SARC	Positive regulation of tumor necrosis factor superfamily cytokine production →	+0.044	+0.374	<.001	<.001	3	26
THCA	Complement activation, classical pathway →	+0.183	+1.340	<.001	<.001	3	26
ESCA	CD4-positive, alpha-beta T cell activation →	+0.046	+1.028	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,926 associations by consensus.

Exploration

IGKV1D-27 survival (RNA) · tumor vs normal (RNA) · all IGKV1D-27 data types