Across TCGA patient cohorts, IGKV1D-27 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGKV1D-27-associated genes across cancer lineages are OR52X1P, TBCAP2, and MTND4LP12. Each is linked with IGKV1D-27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-27-to-partner and partner-to-IGKV1D-27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-27→partner) and Y-score (partner→IGKV1D-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR52X1P →	+0.040	+3.360	<.001	.006	3	1
SKCM	TBCAP2 →	+0.110	+3.253	.002	.003	3	1
SKCM	MTND4LP12 →	+0.062	+4.900	<.001	.002	3	1
SKCM	NDUFA4P2 →	+0.085	+3.300	.005	.007	3	1
SKCM	PRKCIP1 →	+0.055	+3.328	.002	.009	3	1
SKCM	ACTG1P13 →	+0.031	+3.186	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Exploration

IGKV1D-27 survival (RNA) · tumor vs normal (RNA) · all IGKV1D-27 data types