IGKV1D-27

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGKV1D-27 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible IGKV1D-27-associated genes across cancer lineages are CD4+ Tcm and CLP. Each is linked with IGKV1D-27 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKV1D-27-to-partner and partner-to-IGKV1D-27 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV1D-27→partner) and Y-score (partner→IGKV1D-27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCCD4+ Tcm →+0.013+5.468<.001.04331
SKCMCLP →+0.115+2.826.015.03611
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration