IGKV1D-17

Across TCGA pan-cancer cohorts, IGKV1D-17 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV1D-17 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGKV1D-17 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1D-17 expression acts as an unfavorable survival marker.

SKCM, LUAD, and HNSC are the cancer types where IGKV1D-17 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.230	0.781	.004	15	view →
LUAD	DFS	Median	All	0.098	0.768	<.001	9	view →
HNSC	OS	Median	All	0.261	0.686	.035	6	view →
COAD	DFS	Median	IV	0.028	0.496	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV1D-17–SKCM (OS)

Open the SKCM breakdown →