IGKV1-8

Across TCGA pan-cancer cohorts, IGKV1-8 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGKV1-8 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGKV1-8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1-8 expression acts as an unfavorable survival marker.

CCRCC are the cancer types where IGKV1-8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	III,IV	0.406	0.974	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

IGKV1-8–CCRCC (OS)

Open the CCRCC breakdown →