IGKV1-32

Across TCGA pan-cancer cohorts, IGKV1-32 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated IGKV1-32 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1-32 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1-32 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

LUAD, SKCM, and COAD are the cancer types where IGKV1-32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.739	0.510	.001	45	view →
SKCM	OS	Tertile	All	0.474	0.320	.010	42	view →
COAD	OS	Tertile	IV	0.180	0.665	.003	36	view →
GBM	DFS	Tertile	All	0.047	0.258	<.001	18	view →
BRCA	OS	Tertile	IV	1.000	0.634	.030	18	view →
BLCA	OS	Tertile	All	0.888	0.694	.012	15	view →
PAAD	DFS	Tertile	All	0.295	0.493	.006	9	view →
LGG	OS	Tertile	All	0.552	0.889	.005	9	view →
KIRC	DFS	Tertile	III,IV	0.846	0.727	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

IGKV1-32–LUAD (OS)

Open the LUAD breakdown →