IGKV1-27

Across TCGA pan-cancer cohorts, IGKV1-27 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated IGKV1-27 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGKV1-27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGKV1-27 expression acts as an unfavorable survival marker.

LUAD, LUSC, and COAD are the cancer types where IGKV1-27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.111	0.750	<.001	18	view →
LUSC	OS	Median	III,IV	0.112	0.664	.003	12	view →
COAD	OS	Median	II,III,IV	0.168	0.788	.005	12	view →
LIHC	DFS	Median	All	0.097	0.553	.038	6	view →
SKCM	DFS	Median	II,III,IV	0.192	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

IGKV1-27–LUAD (OS)

Open the LUAD breakdown →