IGKV1-27

Across TCGA pan-cancer cohorts, IGKV1-27 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGKV1-27 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGKV1-27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGKV1-27 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

UCEC, CCRCC, and HNSC are the cancer types where IGKV1-27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.758	0.986	.001	62	view →
CCRCC	OS	Median	All	0.952	0.826	.011	9	view →
HNSC	DFS	Median	II,III,IV	0.901	0.987	.026	6	view →
PDAC	DFS	Tertile	III,IV	0.173	0.483	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGKV1-27–UCEC (DFS)

Open the UCEC breakdown →