IGKV1-12

Across TCGA pan-cancer cohorts, IGKV1-12 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IGKV1-12 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGKV1-12 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGKV1-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and CESC are the cancer types where IGKV1-12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.722	0.598	<.001	150	view →
SKCM	OS	Tertile	All	0.453	0.273	<.001	93	view →
CESC	OS	Median	All	0.898	0.702	<.001	76	view →
BRCA	DFS	Median	All	0.968	0.928	<.001	72	view →
KIRC	DFS	Tertile	All	0.460	0.708	.005	55	view →
LUAD	OS	Median	III,IV	0.670	0.334	.003	52	view →
GBM	OS	Tertile	All	0.250	0.447	<.001	45	view →
CHOL	DFS	Quartile	All	0.795	0.209	.004	18	view →
LUSC	DFS	Tertile	III,IV	0.622	0.322	.007	14	view →
READ	DFS	Tertile	IV	0.917	0.534	.017	14	view →
COAD	OS	Tertile	IV	0.883	0.224	.001	11	view →
ACC	DFS	Tertile	III,IV	0.102	0.408	.049	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IGKV1-12–HNSC (OS)

Open the HNSC breakdown →