Across TCGA patient cohorts, IGKC protein abundance is significantly associated with the RNA expression of many other genes, with 17,827 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGKC-associated genes across cancer lineages are IRF4, IGKJ4, and IGHG1. Each is linked with IGKC in more than 8 cancer types. Because this analysis shows association rather than direction, both IGKC-to-partner and partner-to-IGKC results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKC→partner) and Y-score (partner→IGKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF4 →	+1.321	+0.458	<.001	<.001	3	9
BRCA	IGKJ4 →	+2.388	+0.509	<.001	<.001	3	9
BRCA	IGHG1 →	+3.263	+0.670	<.001	<.001	3	9
OV	IGHV6-1 →	+2.801	+0.716	<.001	.003	3	9
UCEC	IGHV1-46 →	+2.674	+0.627	<.001	<.001	3	9
OV	IGKV3-20 →	+2.881	+0.621	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,827 associations by consensus.

Exploration

IGKC survival (RNA) · tumor vs normal (RNA) · all IGKC data types