Across TCGA patient cohorts, IGKC mutation is significantly associated with the RNA expression of many other genes, with 2,507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGKC-associated genes across cancer lineages are RFC3, SUPV3L1, and ZMYND19. Each is linked with IGKC in more than 2 cancer types. Because this analysis shows association rather than direction, both IGKC-to-partner and partner-to-IGKC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKC→partner) and Y-score (partner→IGKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC3 →	+0.773	+2.928	.002	.001	3	3
UCEC	SUPV3L1 →	+0.385	+3.364	.009	.004	3	3
UCEC	ZMYND19 →	+0.383	+2.254	.008	.006	3	3
LUSC	MRPS30 →	+0.433	+2.674	.001	<.001	3	3
LUSC	LINC01370 →	+0.908	+1.939	<.001	.003	3	3
LUSC	MPV17L2 →	+0.397	+2.249	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,507 associations by consensus.

Exploration

IGKC survival (RNA) · tumor vs normal (RNA) · all IGKC data types