Across TCGA patient cohorts, IGKC mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGKC-associated genes across cancer lineages are FASN, EGFR_pY1173, and GSK-3a-b_pS21_S9. Each is linked with IGKC in more than 1 cancer types. Because this analysis shows association rather than direction, both IGKC-to-partner and partner-to-IGKC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKC→partner) and Y-score (partner→IGKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FASN →	+0.503	+1.816	.002	.015	3	2
LUSC	EGFR_pY1173 →	-0.107	-3.459	.038	.004	3	1
LUSC	GSK-3a-b_pS21_S9 →	+0.327	+1.816	.032	.015	3	1
LUSC	Src_pY527 →	+0.314	+1.874	.036	.049	3	1
LUSC	Caspase-9 →	-0.155	-3.169	.001	.016	3	1
SKCM	p90 RSK →	+0.254	+2.700	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

IGKC survival (RNA) · tumor vs normal (RNA) · all IGKC data types