IGIP

Across TCGA patient cohorts, IGIP mutation is significantly associated with the RNA expression of many other genes, with 1,518 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGIP-associated genes across cancer lineages are RNU6-275P, MIR4773-1, and BTBD10. Each is linked with IGIP in more than 1 cancer types. Because this analysis shows association rather than direction, both IGIP-to-partner and partner-to-IGIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-275P grouped by IGIP-low versus IGIP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGIP→partner) and Y-score (partner→IGIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-275P →	+0.201	+5.412	<.001	.001	3	2
COAD	MIR4773-1 →	+0.333	+4.821	<.001	.003	3	2
UCEC	BTBD10 →	+0.605	+3.839	<.001	<.001	3	1
UCEC	PTPRJ →	+0.624	+2.425	.005	.002	3	1
UCEC	LAMTOR1 →	+0.396	+3.098	.002	<.001	3	1
UCEC	CCDC15 →	+0.382	+1.939	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,518 associations by consensus.

RNU6-275P by IGIP expression — COAD

Explore this box plot interactively →