IGHVIII-67-4

Across TCGA pan-cancer cohorts, IGHVIII-67-4 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated IGHVIII-67-4 data layer.

The strongest signal is observed in testicular germ cell tumors (TGCT), where higher IGHVIII-67-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVIII-67-4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.

TGCT, GBM, and PCPG are the cancer types where IGHVIII-67-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
TGCT	OS	Tertile	All	0.672	0.991	<.001	90	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	36	view →
PCPG	OS	Tertile	All	0.792	0.974	.013	36	view →
LUAD	OS	Tertile	All	0.949	0.816	.028	33	view →
READ	DFS	Tertile	III,IV	0.082	0.749	<.001	27	view →
THYM	DFS	Tertile	All	0.730	0.933	.017	21	view →
LUSC	DFS	Tertile	II,III,IV	0.230	0.415	.023	21	view →
DLBC	OS	Tertile	II,III,IV	0.118	0.802	.025	18	view →
ESCA	DFS	Tertile	II,III,IV	0.796	0.277	.031	6	view →
SKCM	OS	Tertile	All	0.832	0.876	.048	3	view →
KIRP	DFS	Tertile	All	1.000	0.577	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

IGHVIII-67-4–TGCT (OS)

Open the TGCT breakdown →