IGHVIII-5-1

Across TCGA pan-cancer cohorts, IGHVIII-5-1 RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated IGHVIII-5-1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHVIII-5-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVIII-5-1 expression acts as an unfavorable survival marker, although some lineages such as READ show a favorable association.

LUAD, GBM, and LAML are the cancer types where IGHVIII-5-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.183	0.388	.008	21	view →
GBM	DFS	Tertile	All	0.064	0.257	.014	18	view →
LAML	DFS	Tertile	All	0.250	0.592	.015	18	view →
PCPG	OS	Tertile	All	0.539	0.849	.006	18	view →
COAD	DFS	Tertile	II,III,IV	0.568	0.755	.046	9	view →
SARC	DFS	Tertile	All	0.107	0.402	.012	9	view →
READ	DFS	Tertile	III,IV	1.000	0.222	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHVIII-5-1–LUAD (OS)

Open the LUAD breakdown →