IGHVIII-38-1

Across TCGA pan-cancer cohorts, IGHVIII-38-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHVIII-38-1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHVIII-38-1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHVIII-38-1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LAML show a favorable association.

LUAD, KIRP, and LAML are the cancer types where IGHVIII-38-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.643	0.276	.003	81	view →
KIRP	DFS	Tertile	II,III,IV	0.093	0.536	.009	36	view →
LAML	DFS	Tertile	All	0.717	0.470	.014	32	view →
SKCM	DFS	Tertile	All	0.278	0.166	<.001	29	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
UVM	DFS	Tertile	All	0.339	0.748	.045	18	view →
OV	OS	Tertile	All	0.598	0.699	.019	18	view →
UCS	DFS	Tertile	II,III,IV	0.743	0.351	.021	18	view →
LUSC	OS	Tertile	III,IV	0.182	0.794	.001	18	view →
THYM	OS	Tertile	All	1.000	0.679	.002	17	view →
BRCA	OS	Tertile	III,IV	0.981	0.889	.031	12	view →
PCPG	DFS	Tertile	All	0.229	0.822	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHVIII-38-1–LUAD (DFS)

Open the LUAD breakdown →