IGHVII-74-1

Across TCGA pan-cancer cohorts, IGHVII-74-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated IGHVII-74-1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IGHVII-74-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated IGHVII-74-1 expression acts as an unfavorable survival marker, although some lineages such as LAML and BLCA show a favorable association.

KIRC, READ, and SARC are the cancer types where IGHVII-74-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.471	0.662	<.001	126	view →
READ	DFS	Tertile	All	0.027	0.820	<.001	72	view →
SARC	OS	Tertile	All	0.189	0.866	<.001	36	view →
LAML	DFS	Tertile	All	0.725	0.489	.016	22	view →
GBM	OS	Tertile	All	0.030	0.416	<.001	18	view →
ACC	DFS	Tertile	III,IV	0.048	0.457	.015	18	view →
LGG	DFS	Tertile	All	0.118	0.826	<.001	15	view →
BLCA	OS	Tertile	II,III,IV	0.797	0.589	.025	12	view →
PAAD	DFS	Tertile	All	0.219	0.489	.042	9	view →
COAD	DFS	Tertile	All	0.403	0.692	.045	9	view →
MESO	OS	Tertile	All	0.362	0.569	.046	9	view →
KIRP	DFS	Tertile	All	0.157	0.867	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

IGHVII-74-1–KIRC (OS)

Open the KIRC breakdown →