Across TCGA pan-cancer cohorts, IGHV6-1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV6-1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV6-1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated IGHV6-1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where IGHV6-1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.964	0.166	.010	36	view →
CCRCC	DFS	Tertile	All	0.851	0.535	.009	11	view →
PDAC	OS	Quartile	II,III,IV	0.606	0.379	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IGHV6-1 tumor-vs-normal RNA expression · all IGHV6-1 data types