Across TCGA patient cohorts, IGHV6-1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,260 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV6-1-associated genes across cancer lineages are P2RX1, KLHL6, and NCF1B. Each is linked with IGHV6-1 in more than 5 cancer types. Because this analysis shows association rather than direction, both IGHV6-1-to-partner and partner-to-IGHV6-1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV6-1→partner) and Y-score (partner→IGHV6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	P2RX1 →	+0.591	+0.541	.002	.002	3	6
HNSC	KLHL6 →	+0.777	+0.671	.001	<.001	3	6
HNSC	NCF1B →	+0.706	+0.702	<.001	<.001	3	6
OV	IGKV3D-20 →	+2.526	+1.102	.001	.002	3	6
OV	IGKV1D-39 →	+2.799	+1.141	.001	.004	3	6
HNSC	CYTH4 →	+1.110	+0.661	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,260 associations by consensus.

Exploration

IGHV6-1 survival (RNA) · tumor vs normal (RNA) · all IGHV6-1 data types