Across TCGA patient cohorts, IGHV5-51 protein abundance is significantly associated with the RNA expression of many other genes, with 14,126 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV5-51-associated genes across cancer lineages are LAX1, FCRL5, and IGHV3-74. Each is linked with IGHV5-51 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV5-51-to-partner and partner-to-IGHV5-51 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV5-51→partner) and Y-score (partner→IGHV5-51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LAX1 →	+0.914	+0.409	<.001	<.001	3	7
LUAD	FCRL5 →	+1.100	+0.419	<.001	<.001	3	7
OV	IGHV3-74 →	+2.047	+0.760	<.001	.001	3	7
OV	IGHV6-1 →	+2.987	+0.808	<.001	.005	3	7
OV	IGKV3-20 →	+2.418	+0.709	<.001	<.001	3	7
UCEC	IGKV1-16 →	+2.598	+0.577	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,126 associations by consensus.

Exploration

IGHV5-51 survival (RNA) · tumor vs normal (RNA) · all IGHV5-51 data types