Across TCGA patient cohorts, IGHV5-51 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV5-51-associated genes across cancer lineages are iDC, Adipocytes, and Melanocytes. Each is linked with IGHV5-51 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV5-51-to-partner and partner-to-IGHV5-51 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV5-51→partner) and Y-score (partner→IGHV5-51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	iDC →	-0.161	-2.990	.036	.036	3	1
UCEC	Adipocytes →	+0.021	+2.729	.023	.009	3	1
UCEC	Melanocytes →	-0.012	-2.903	.036	.037	3	1
UCEC	Myocytes →	+0.038	+2.212	.023	.034	3	1
UCEC	Th2 cells →	+0.215	+2.815	.023	.036	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

IGHV5-51 survival (RNA) · tumor vs normal (RNA) · all IGHV5-51 data types