Across TCGA patient cohorts, IGHV4-61 mutation is significantly associated with the RNA expression of many other genes, with 424 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-61-associated genes across cancer lineages are C2orf69P4, RPSAP64, and RNU6-1246P. Each is linked with IGHV4-61 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-61-to-partner and partner-to-IGHV4-61 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-61→partner) and Y-score (partner→IGHV4-61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C2orf69P4 →	+0.084	+7.741	<.001	.009	3	2
UCEC	RPSAP64 →	+0.567	+3.914	<.001	.002	3	2
SKCM	RNU6-1246P →	+0.078	+3.903	<.001	.007	3	2
LUSC	UBE2V1P10 →	+0.118	+4.706	<.001	.007	3	2
BRCA	FAM30B →	+0.152	+7.038	<.001	<.001	3	1
UCEC	LINC01050 →	+0.280	+3.801	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 424 associations by consensus.

Exploration

IGHV4-61 survival (RNA) · tumor vs normal (RNA) · all IGHV4-61 data types