IGHV4-61

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV4-61 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible IGHV4-61-associated genes across cancer lineages are MPP and CD4+ naive T-cells. Each is linked with IGHV4-61 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-61-to-partner and partner-to-IGHV4-61 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-61→partner) and Y-score (partner→IGHV4-61) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUSCMPP →+0.009+3.694.023.02732
LUADCD4+ naive T-cells →+0.034+3.640.010.02431
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Exploration