Across TCGA pan-cancer cohorts, IGHV4-59 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of IGHV4-59’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where IGHV4-59 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IGHV4-59 is over-expressed in tumor.

LSCC are the cancer types where IGHV4-59 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IGHV4-59 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+1.515	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: IGHV4-59 RNA expression & survival · all IGHV4-59 data types