IGHV4-59

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV4-59 mutation is significantly associated with the RNA expression of many other genes, with 426 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-59-associated genes across cancer lineages are RN7SKP186, RNU6-763P, and MRPL35P1. Each is linked with IGHV4-59 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-59-to-partner and partner-to-IGHV4-59 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-59→partner) and Y-score (partner→IGHV4-59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRN7SKP186 →+1.802+5.888<.001.00232
LUADRNU6-763P →+1.077+7.333<.001<.00132
LUADMRPL35P1 →+0.301+4.990<.001.00932
LUADRNU4-26P →+1.266+5.410<.001.00532
LUADMIR8057 →+0.979+5.157<.001.00732
HNSCRN7SKP250 →+0.230+5.182<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 426 associations by consensus.

Exploration