Across TCGA patient cohorts, IGHV4-59 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-59-associated genes across cancer lineages are Smac, ER-alpha, and PKC-a_pS657. Each is linked with IGHV4-59 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-59-to-partner and partner-to-IGHV4-59 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-59→partner) and Y-score (partner→IGHV4-59) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.339	+2.820	.011	.035	3	2
SKCM	ER-alpha →	-0.223	-2.288	.016	.032	3	1
SKCM	PKC-a_pS657 →	-0.472	-3.000	.014	.034	3	1
SKCM	PKC-a →	-0.527	-3.000	.009	.034	3	1
SKCM	STAT3_pY705 →	-0.351	-3.459	.009	.005	3	1
SKCM	XRCC1 →	+0.264	+2.820	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

IGHV4-59 survival (RNA) · tumor vs normal (RNA) · all IGHV4-59 data types