IGHV4-55

Across TCGA pan-cancer cohorts, IGHV4-55 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IGHV4-55 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher IGHV4-55 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV4-55 expression acts as an unfavorable survival marker.

THYM, LGG, and LUSC are the cancer types where IGHV4-55 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LGG	OS	Median	All	0.195	0.896	<.001	12	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

IGHV4-55–THYM (OS)

Open the THYM breakdown →