Across TCGA patient cohorts, IGHV4-39 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-39-associated genes across cancer lineages are RN7SL478P, RNU6-63P, and RNU6-557P. Each is linked with IGHV4-39 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-39-to-partner and partner-to-IGHV4-39 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-39→partner) and Y-score (partner→IGHV4-39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL478P →	+0.197	+3.683	<.001	<.001	3	1
SKCM	RNU6-63P →	+0.222	+3.422	.002	.006	3	1
SKCM	RNU6-557P →	+0.176	+3.776	<.001	.003	3	1
SKCM	RNU6-1092P →	+0.410	+3.487	<.001	.005	3	1
SKCM	CDH12P3 →	+0.073	+3.699	<.001	.003	3	1
SKCM	OR4A7P →	+0.019	+5.643	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

IGHV4-39 survival (RNA) · tumor vs normal (RNA) · all IGHV4-39 data types