Across TCGA patient cohorts, IGHV4-39 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV4-39-associated genes across cancer lineages are MEP, Osteoblast, and Pericytes. Each is linked with IGHV4-39 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-39-to-partner and partner-to-IGHV4-39 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-39→partner) and Y-score (partner→IGHV4-39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEP →	+0.051	+2.839	.002	.035	3	1
SKCM	Osteoblast →	+0.064	+2.813	.004	.037	3	1
UCEC	Pericytes →	+0.067	+2.113	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

IGHV4-39 survival (RNA) · tumor vs normal (RNA) · all IGHV4-39 data types