Across TCGA pan-cancer cohorts, IGHV4-28 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGHV4-28 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV4-28 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV4-28 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC are the cancer types where IGHV4-28 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.315	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: IGHV4-28 tumor-vs-normal RNA expression · all IGHV4-28 data types