Across TCGA pan-cancer cohorts, IGHV4-28 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGHV4-28 data layer compared with 25 for mass-spec protein and 1 for mutation status.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV4-28 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV4-28 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.
UCEC, HNSC, and LSCC are the cancer types where IGHV4-28 mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.