Across TCGA patient cohorts, IGHV4-28 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV4-28-associated genes across cancer lineages are EGFR_pY1173, FOXO3a, and MEK1. Each is linked with IGHV4-28 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV4-28-to-partner and partner-to-IGHV4-28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-28→partner) and Y-score (partner→IGHV4-28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.086	+3.196	.049	.010	3	1
UCEC	FOXO3a →	+0.135	+2.820	.015	.035	3	1
SKCM	MEK1 →	+0.507	+3.000	.012	.036	1	2
SKCM	VEGFR2 →	+0.348	+3.000	.025	.036	2	1
UCEC	Notch1 →	+0.170	+3.169	.028	.020	1	1
UCEC	Caspase-8 →	-0.287	-3.169	.038	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

IGHV4-28 survival (RNA) · tumor vs normal (RNA) · all IGHV4-28 data types