IGHV3OR16-9

Across TCGA pan-cancer cohorts, IGHV3OR16-9 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated IGHV3OR16-9 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV3OR16-9 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3OR16-9 expression acts as an unfavorable survival marker.

LUAD, UCEC, and HNSC are the cancer types where IGHV3OR16-9 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.156	0.872	<.001	80	view →
UCEC	DFS	Median	II,III,IV	0.317	0.905	.006	32	view →
HNSC	OS	Tertile	All	0.727	0.968	.029	9	view →
LSCC	DFS	Median	II,III,IV	0.517	0.830	.008	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

IGHV3OR16-9–LUAD (OS)

Open the LUAD breakdown →