IGHV3OR16-13

Across TCGA pan-cancer cohorts, IGHV3OR16-13 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-13 data layer compared with 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-13 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and BRCA are the cancer types where IGHV3OR16-13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.396	0.258	<.001	142	view →
SKCM	OS	Tertile	All	0.466	0.278	<.001	115	view →
BRCA	DFS	Median	All	0.970	0.928	<.001	102	view →
KIRP	DFS	Quartile	All	0.518	0.861	.004	34	view →
DLBC	DFS	Tertile	All	0.337	0.799	.014	26	view →
OV	DFS	Quartile	II,III,IV	0.453	0.351	.017	22	view →
COAD	DFS	Median	All	0.747	0.637	.006	21	view →
CHOL	DFS	Quartile	All	0.794	0.265	.009	18	view →
LUAD	OS	Quartile	II,III,IV	0.700	0.322	.013	15	view →
UCEC	OS	Tertile	III,IV	0.725	0.515	.022	14	view →
SARC	OS	Tertile	All	0.927	0.800	.005	13	view →
PAAD	DFS	Quartile	II,III,IV	0.577	0.309	.005	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

IGHV3OR16-13–HNSC (DFS)

Open the HNSC breakdown →