IGHV3OR16-12

Across TCGA pan-cancer cohorts, IGHV3OR16-12 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGHV3OR16-12 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHV3OR16-12 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-12 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

COAD, HNSC, and UCEC are the cancer types where IGHV3OR16-12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.565	1.000	.028	24	view →
HNSC	DFS	Tertile	III,IV	0.931	0.702	.004	12	view →
UCEC	DFS	Median	All	0.841	0.961	.015	8	view →
GBM	DFS	Median	All	0.516	0.243	.004	6	view →
CCRCC	DFS	Quartile	III,IV	0.140	0.830	.038	6	view →
OV	DFS	Median	All	1.000	0.867	.040	4	view →
LUAD	OS	Tertile	All	0.783	0.899	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHV3OR16-12–COAD (DFS)

Open the COAD breakdown →