IGHV3OR16-11

Across TCGA pan-cancer cohorts, IGHV3OR16-11 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated IGHV3OR16-11 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3OR16-11 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3OR16-11 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

HNSC, UVM, and COAD are the cancer types where IGHV3OR16-11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.756	0.636	<.001	138	view →
UVM	OS	Tertile	All	0.315	0.864	<.001	99	view →
COAD	DFS	Median	II,III,IV	0.733	0.601	.004	61	view →
CESC	DFS	Median	All	0.813	0.660	.001	58	view →
SKCM	OS	Median	All	0.931	0.807	.002	45	view →
LUAD	OS	Quartile	III,IV	0.707	0.211	.006	27	view →
CHOL	DFS	Tertile	All	0.809	0.257	.002	26	view →
DLBC	DFS	Tertile	II,III,IV	1.000	0.403	.011	24	view →
BLCA	DFS	Median	All	0.454	0.203	.026	20	view →
LGG	DFS	Tertile	All	0.299	0.735	<.001	18	view →
KIRP	DFS	Tertile	IV	1.000	0.139	.018	17	view →
OV	OS	Quartile	III,IV	0.770	0.862	.016	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

IGHV3OR16-11–HNSC (DFS)

Open the HNSC breakdown →