IGHV3OR15-7

Across TCGA pan-cancer cohorts, IGHV3OR15-7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGHV3OR15-7 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IGHV3OR15-7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3OR15-7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

COAD, UCEC, and CCRCC are the cancer types where IGHV3OR15-7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.914	1.000	.013	66	view →
UCEC	DFS	Tertile	All	0.690	0.981	.002	52	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	22	view →
GBM	OS	Quartile	All	0.248	0.554	.013	7	view →
HNSC	DFS	Quartile	All	0.947	0.326	.024	7	view →
PDAC	OS	Median	III,IV	0.332	0.591	.044	2	view →
LSCC	DFS	Median	II,III,IV	0.868	0.965	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

IGHV3OR15-7–COAD (DFS)

Open the COAD breakdown →