IGHV3-75

Across TCGA pan-cancer cohorts, IGHV3-75 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated IGHV3-75 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IGHV3-75 RNA is associated with better overall survival. In most high-consensus cancer types, elevated IGHV3-75 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and ACC are the cancer types where IGHV3-75 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.840	0.693	<.001	127	view →
SKCM	DFS	Tertile	All	0.694	0.576	.001	90	view →
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	87	view →
CESC	OS	Tertile	All	0.902	0.721	<.001	78	view →
DLBC	DFS	Tertile	All	0.531	1.000	.003	73	view →
KIRP	DFS	Tertile	II,III,IV	0.570	0.826	<.001	67	view →
BRCA	OS	Tertile	All	0.981	0.946	.001	54	view →
UVM	OS	Tertile	All	0.551	0.878	<.001	54	view →
READ	DFS	Median	II,III,IV	0.900	0.714	.006	30	view →
BLCA	DFS	Median	IV	0.095	0.321	.002	27	view →
LGG	DFS	Tertile	All	0.123	0.404	.001	24	view →
LUAD	OS	Tertile	II,III,IV	0.721	0.376	.003	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

IGHV3-75–HNSC (OS)

Open the HNSC breakdown →