Across TCGA pan-cancer cohorts, IGHV3-74 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated IGHV3-74 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV3-74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-74 expression acts as an unfavorable survival marker.

UCEC are the cancer types where IGHV3-74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: IGHV3-74 tumor-vs-normal RNA expression · all IGHV3-74 data types