Across TCGA pan-cancer cohorts, IGHV3-74 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGHV3-74 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGHV3-74 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV3-74 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where IGHV3-74 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	1.000	0.778	.006	31	view →
LUAD	DFS	Median	III,IV	0.249	0.775	.006	16	view →
UCEC	DFS	Median	All	0.827	0.970	.014	12	view →
PDAC	DFS	Tertile	II,III,IV	0.625	0.345	.013	11	view →
LSCC	DFS	Quartile	All	1.000	0.326	.010	4	view →
HNSC	DFS	Median	IV	1.000	0.661	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGHV3-74 tumor-vs-normal RNA expression · all IGHV3-74 data types