Across TCGA patient cohorts, IGHV3-74 protein abundance is significantly associated with the RNA expression of many other genes, with 7,193 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV3-74-associated genes across cancer lineages are IGKV4-1, IGLV3-25, and IGHG1. Each is linked with IGHV3-74 in more than 3 cancer types. Because this analysis shows association rather than direction, both IGHV3-74-to-partner and partner-to-IGHV3-74 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-74→partner) and Y-score (partner→IGHV3-74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGKV4-1 →	+2.246	+0.977	<.001	<.001	3	4
UCEC	IGLV3-25 →	+2.127	+1.316	<.001	<.001	3	4
UCEC	IGHG1 →	+3.255	+1.810	<.001	<.001	3	4
BRCA	IGHV1-3 →	+2.266	+1.092	.009	.002	3	4
BRCA	IGHV1-18 →	+2.953	+1.732	<.001	<.001	3	4
BRCA	IGHV3-21 →	+2.070	+1.233	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,193 associations by consensus.

Exploration

IGHV3-74 survival (RNA) · tumor vs normal (RNA) · all IGHV3-74 data types