Across TCGA patient cohorts, IGHV3-74 mutation is significantly associated with the RNA expression of many other genes, with 210 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible IGHV3-74-associated genes across cancer lineages are RNU6-553P, RNU7-110P, and MIR6877. Each is linked with IGHV3-74 in more than 1 cancer types. Because this analysis shows association rather than direction, both IGHV3-74-to-partner and partner-to-IGHV3-74 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-74→partner) and Y-score (partner→IGHV3-74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-553P →	+0.441	+2.267	<.001	.003	3	2
UCEC	RNU7-110P →	+1.023	+4.871	<.001	.002	3	2
UCEC	MIR6877 →	+0.957	+4.633	<.001	.004	3	1
UCEC	MIR6803 →	+0.695	+7.478	<.001	<.001	3	1
SKCM	HNRNPUL2-BSCL2 →	+0.378	+2.719	<.001	.003	3	1
SKCM	GUSBP17 →	+0.124	+2.410	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 210 associations by consensus.

Exploration

IGHV3-74 survival (RNA) · tumor vs normal (RNA) · all IGHV3-74 data types