Across TCGA pan-cancer cohorts, IGHV3-73 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IGHV3-73 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher IGHV3-73 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-73 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where IGHV3-73 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	40	view →
CCRCC	OS	Median	IV	0.785	0.123	.009	21	view →
LSCC	DFS	Quartile	All	0.906	0.700	.006	12	view →
PDAC	DFS	Quartile	All	0.819	0.416	.002	8	view →
HNSC	DFS	Quartile	II,III,IV	0.910	1.000	.037	1	view →
LUAD	DFS	Tertile	III,IV	0.633	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: IGHV3-73 tumor-vs-normal RNA expression · all IGHV3-73 data types