Across TCGA pan-cancer cohorts, IGHV3-72 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGHV3-72 data layer compared with 24 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher IGHV3-72 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated IGHV3-72 expression acts as an unfavorable survival marker.

SKCM and BLCA are the cancer types where IGHV3-72 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	III,IV	0.065	0.616	<.001	19	view →
BLCA	DFS	Median	III,IV	0.083	0.572	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGHV3-72 tumor-vs-normal RNA expression · all IGHV3-72 data types