Across TCGA patient cohorts, IGHV3-72 protein abundance is significantly associated with the protein abundance of many other proteins, with 21,805 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible IGHV3-72-associated proteins across cancer lineages are SERPINA1, SERPINA3, and SERPINA6. Each is linked with IGHV3-72 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV3-72-to-partner and partner-to-IGHV3-72 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-72→partner) and Y-score (partner→IGHV3-72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERPINA1 →	+0.891	+0.689	<.001	<.001	3	10
OV	SERPINA3 →	+0.910	+0.921	<.001	<.001	3	10
GBM	SERPINA6 →	+0.903	+0.926	<.001	<.001	3	10
GBM	SERPIND1 →	+0.850	+0.710	<.001	<.001	3	10
OV	SERPINF2 →	+1.016	+1.044	<.001	<.001	3	10
OV	IGHV3OR15-7 →	+1.224	+1.100	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,805 associations by consensus.

Exploration

IGHV3-72 survival (RNA) · tumor vs normal (RNA) · all IGHV3-72 data types