Across TCGA patient cohorts, IGHV3-7 protein abundance is significantly associated with the RNA expression of many other genes, with 15,720 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV3-7-associated genes across cancer lineages are IRF4, PIK3R5, and FCRL5. Each is linked with IGHV3-7 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV3-7-to-partner and partner-to-IGHV3-7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-7→partner) and Y-score (partner→IGHV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IRF4 →	+0.999	+0.511	<.001	<.001	3	7
GBM	PIK3R5 →	+0.965	+0.880	<.001	<.001	3	6
LSCC	FCRL5 →	+1.041	+0.592	<.001	<.001	3	6
GBM	IGKJ5 →	+1.808	+0.773	<.001	<.001	3	6
OV	IGKV4-1 →	+2.260	+0.529	.002	.009	3	6
OV	IGKV3D-20 →	+1.786	+0.646	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,720 associations by consensus.

Exploration

IGHV3-7 survival (RNA) · tumor vs normal (RNA) · all IGHV3-7 data types