Across TCGA cell cohorts, IGHV3-7 protein abundance is significantly associated with the RNA expression of many other genes, with 3,416 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IGHV3-7-associated genes across cancer lineages are AKR7A2, MTHFR, and SLC66A1. Each is linked with IGHV3-7 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV3-7-to-partner and partner-to-IGHV3-7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV3-7→partner) and Y-score (partner→IGHV3-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AKR7A2 →	+1.220	+1.896	.002	.002	3	10
LUNG_NSCLC_LUSC	MTHFR →	+1.297	+1.507	<.001	.001	3	7
BLOOD_Leukemia	SLC66A1 →	+1.552	+0.960	<.001	.001	3	7
BREAST	AKR7A3 →	+1.673	+1.673	.009	.001	3	6
LARGE_INTESTINE	DGCR6 →	+1.235	+0.915	.004	.001	3	6
BONE	KLHL22 →	+0.730	+0.826	.006	.005	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,416 associations by consensus.

Exploration

IGHV3-7 survival (RNA) · tumor vs normal (RNA) · all IGHV3-7 data types