Across TCGA pan-cancer cohorts, IGHV3-66 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated IGHV3-66 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher IGHV3-66 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IGHV3-66 expression acts as an unfavorable survival marker.

LUAD and SKCM are the cancer types where IGHV3-66 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.536	0.813	.013	10	view →
SKCM	OS	Median	All	0.217	0.780	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: IGHV3-66 tumor-vs-normal RNA expression · all IGHV3-66 data types